Coppersafe by Mardel in Your Aquarium

Copper sulfate crystals

Since 1956, copper sulfate, an inorganic chemical containing sulfur and copper, has been approved for usage in the United States. It's commonly used as a fungicide in fruit and vegetable production. It comes in three forms: dust, wettable powder, and liquid.

Pyrotechnics make use of copper sulfate to generate beautiful blue explosions. It's been utilized as a dye as well as in electroplating. It's utilized as an algicide and parasite treatment in aquaculture. It should not be used with any invertebrates.

Conditions that copper sulfate is used to treat include the following:

  • Ichthyophthirius multifiliis - Small white spots resembling sand or salt granules on the fish's skin. This is caused by a protozoa and causes the fish to scratch against objects. Use as a prophylactic treatment for quarantine tanks.
  • Other Protozoan infections
  • Removal of snails

Products Containing Copper Sulfate

Mardel Coppersafe 

  • Manufacturer's Directions for Use: Use 5 ml for 4 gallons of water. Loosen measuring chamber cap and squeeze bottle to fill to the desired level. One application treats water for one month. DO NOT overdose.
  • Active Ingredients: Chelated Copper Sulfate.
  • Benefit: CopperSafe is a chelated copper compound that is used for the treatment of infections of Ich (Ichthyophthirius in freshwater and Cryptocaryon in saltwater), Flukes (Gyrodactylus), Anchor Worms (Lernaea), Velvet (Oodinium) disease and other external parasites, according to the brand. CopperSafe, when used as directed, maintains a total copper level of 1.5 ppm to 2.0 ppm in the water. CopperSafe remains active for over one month in the aquarium. Levels of 0.3 ppm free copper are recommended in the literature for therapeutic use, but with Coppersafe, the levels of free copper will be measured at 1.5 ppm to 2.0 ppm. This level of copper can be used in the treatment of fish due to Coppersafe's unique chelating agent. The chelating agent binds with the copper making it nontoxic to fish, but effective against parasites. CopperSafe does not discolor the water and will not interfere with the biological filter
  • Use: CopperSafe should be used when a diagnosis of the fish's illness indicates the presence of Ich, Flukes (Gyrodactylus), Anchor Worms, Velvet Disease and other external freshwater parasites.


According to the company, CopperSafe might be detrimental to plants, amphibians, and snails. Plants and invertebrates without an exoskeleton, such as jellyfish and anemones, should be removed from the aquarium if at all feasible. Otherwise, isolate the fish in a different tank. Keep out of children's reach. Only for aquarium usage. CopperSafe is just for ornamental fish and/or ornamental creatures, and not for people or fish for human food.

CopperSafe must be measured using a chelated or total copper test kit. When utilizing certain test kits, Coppersafe may generate erroneous free copper results. The total copper or chelated copper values, not the free copper results, should be used for all readings.

UV sterilizers, protein skimmers, wet/dry, and diatomaceous earth filters are all safe to use with Coppersafe. Water changes, new activated carbon, or other chemical filtration resins/pads can be used to remove Coppersafe from the aquarium after treatment.

CopperSafe comes in 100 ml, 250 ml, 500 ml, 2 liter and 20-liter sizes.

Seachem Cupramine 

Directions for Use from the Manufacturer: Copper is very harmful to many invertebrates and can be hazardous to some delicate fish species. All invertebrates should be removed. During treatment, turn off the UV sterilizer and remove the chemical filtration.

If the bottle has a dropper cap, use 20 drops (1 mL) per 40 L (10.5 gallons) the first day for saltwater aquariums, then wait 48 hours before repeating. Each inner ring on non-dropper caps is 1 mL. Use half the saltwater dosage in freshwater. In seawater, the final copper concentration is 0.5 mg/L (0.25 mg/L in freshwater). Allow 14 days at this concentration. Do not re-dose until you have tested your levels with MultiTest Copper (DFS# 4343010).

Use with caution if you are taking any other medications. Test copper levels after initial dose if the aquarium has ever been treated with an ionic copper (e.g. copper chloride, sulfate, or citrate). Although most fish tolerate Cupramine up to 0.8 mg/L, above 0.6 mg/L copper is not recommended. Activated carbon and water changes are used to remove it.